Tumor-associated astrocytes augment cholesterol synthesis to support glioblastoma growth through alternatively spliced QKI isoforms
QKI-5 drives astrocytic metabolic reprogramming via the QKI-5-SREBP2 axis, fostering a cholesterol-rich tumor microenvironment that supports GBM progression. Targeting this pathway offers a potential therapeutic strategy.
Authors
- Deanna Tiek (ORCID: https://orcid.org/0000-0002-2881-7691)
- N. Zhang
- Qiu He
- Runxin Wu (ORCID: https://orcid.org/0009-0001-4417-2694)
- Maya Walker
- Xiaozhou Yu (ORCID: https://orcid.org/0000-0002-9187-2896)
- Bo Hu (ORCID: https://orcid.org/0009-0001-6316-3339)
- Derek Sisbarro
- Shi-Yuan Cheng
- Xiao Song
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1093/neuonc/noag030
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00