Interplay of Tumor Morphology and Biology with Postoperative Complications: Prognostic Implications After Resection of Colorectal Liver Metastasis

Postoperative complications had a variable prognostic impact on patients undergoing resection for CRLM depending on the severity of the complication and the overall biologic risk of the underlying disease. Patients with more favorable underlying tumor biology were more likely to have adverse oncologic long-term outcomes after experiencing severe postoperative complications.

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Publication Details

Journal
Annals of Surgical Oncology
Published
2026-02-18
DOI
https://doi.org/10.1245/s10434-026-19229-5
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
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article

Interplay of Tumor Morphology and Biology with Postoperative Complications: Prognostic Implications After Resection of Colorectal Liver Metastasis

Mujtaba Khalil, Miho Akabane, Shahzaib Zindani, Minoru Kitago et al.
Annals of Surgical Oncology
Hepatocellular Carcinoma Treatment and Prognosis
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Interplay of Tumor Morphology and Biology with Postoperative Complications: Prognostic Implications After Resection of Colorectal Liver Metastasis

Mujtaba Khalil, Miho Akabane, Shahzaib Zindani, Minoru Kitago, Kathleen Tong, Timothy M. Pawlik, Irinel Popescu, Kazunari Sasaki, George Poultsides, Areesh Mevawalla, Zayed Rashid, Itaru Endo, Luca Aldrighetti, Federico Aucejo, Azza Sarfraz, Abdullah Altaf, Andrea Ruzzenente
article en

Abstract

Postoperative complications had a variable prognostic impact on patients undergoing resection for CRLM depending on the severity of the complication and the overall biologic risk of the underlying disease. Patients with more favorable underlying tumor biology were more likely to have adverse oncologic long-term outcomes after experiencing severe postoperative complications.

Annals of Surgical Oncology
University of Verona (IT), Cleveland Clinic (US), Keio University (JP), Cleveland Foundation (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), The Ohio State University Wexner Medical Center (US), Institutul Clinic Fundeni (RO), Yokohama City University (JP), Stanford University (US)
Openalex Percentile: Top 52%
Hepatocellular Carcinoma Treatment and Prognosis
DOIOpen Access PDFOpenAlex
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Interplay of Tumor Morphology and Biology with Postoperative Complications: Prognostic Implications After Resection of Colorectal Liver Metastasis — Mujtaba Khalil, Miho Akabane, et al. · Annals of Surgical Oncology (2026) | TGRS Research Map | TGRS