Evaluating Basigin as a Potential Biomarker of Blood–Brain Barrier Dysfunction in Cerebral Amyloid Angiopathy

CSF concentrations of BSG may be related to altered expression at the BBB; the BSG concentrations in CSF may thus serve as a biomarker of BBB function, although a contribution of choroid plexus epithelial BSG cannot be entirely excluded. Independent cohorts are needed to replicate these observations before we can conclude that reduced CSF concentrations of BSG may indicate an alteration of the BBB in patients with CAA.

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Publication Details

Journal
Neuropathology and Applied Neurobiology
Published
2026-02-01
DOI
https://doi.org/10.1111/nan.70064
Primary Topic
Signaling Pathways in Disease
Type
article
Field-Weighted Citation Impact
0.00

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article

Evaluating Basigin as a Potential Biomarker of Blood–Brain Barrier Dysfunction in Cerebral Amyloid Angiopathy

F. Schreuder, Benno Küsters, Lieke Jäkel, Arno Stellingwerf et al.
Neuropathology and Applied Neurobiology
Signaling Pathways in Disease
article

Evaluating Basigin as a Potential Biomarker of Blood–Brain Barrier Dysfunction in Cerebral Amyloid Angiopathy

F. Schreuder, Benno Küsters, Lieke Jäkel, Arno Stellingwerf, Davita Bosveld, Catharina J M Klijn, Marcel M. Verbeek, H. Bea Kuiperij, Anna M. De Kort
article en

Abstract

CSF concentrations of BSG may be related to altered expression at the BBB; the BSG concentrations in CSF may thus serve as a biomarker of BBB function, although a contribution of choroid plexus epithelial BSG cannot be entirely excluded. Independent cohorts are needed to replicate these observations before we can conclude that reduced CSF concentrations of BSG may indicate an alteration of the BBB in patients with CAA.

Neuropathology and Applied NeurobiologyVol. 52(1)
Radboud University Nijmegen (NL), Radboud University Medical Center (NL)
ZonMw, Leids Universitair Medisch Centrum, Radboud Universitair Medisch Centrum, Alzheimer Nederland, National Institutes of Health
Openalex Percentile: Top 52%
Signaling Pathways in Disease
DOIOpen Access PDFOpenAlex
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