Concurrent driver mutations induce distinct tumour morphologies on radiological imaging
Across different cancers, CT radiomics identified genotype-specific phenotypes and showed that co-mutations produce distinct morphologies. Co-mutation context should be modelled explicitly in radiogenomics and prospectively validated for non-invasive molecular stratification.
Authors
- Kalina Chupetlovska (ORCID: https://orcid.org/0000-0002-1183-7426)
- Federica Landolfi (ORCID: https://orcid.org/0000-0002-2208-2559)
- Sajjad Rostami
- Zuhir Bodalal (ORCID: https://orcid.org/0000-0002-2617-8128)
- Francesca Castagnoli (ORCID: https://orcid.org/0000-0003-2407-7451)
- Olga Maxouri (ORCID: https://orcid.org/0000-0002-4709-1929)
- Diana Ivonne Rodríguez Sánchez
- Julian Middelkoop
- Thera Vanneste
- Regina Beets-Tan
- Nino Boveradze
- Nicolo Gennaro
- Stephan Ursprung
- Eun Kyoung Hong
- Petur Snaebjornsson
Institutions
- University of Iceland (IS)
- Palo Alto University (US)
- The Netherlands Cancer Institute (NL)
- Maastricht University (NL)
- University of Chieti-Pescara (IT)
- Ente Ospedaliero Cantonale (CH)
- Oncode Institute (NL)
- Royal Marsden Hospital (GB)
- Icelandic Cancer Society (IS)
- Maastro Clinic (NL)
- University of Tübingen (DE)
- Sapienza University of Rome (IT)
- Stanford University (US)
Publication Details
- Journal
- European Journal of Radiology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.ejrad.2026.112738
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nvidia
- European Commission