Nutrient Restriction Improves the Therapeutic Efficacy of Sorafenib by Inducing Ferroptosis via the NRF2/HO-1/GPX4 Pathway in Hepatocellular Carcinoma
The combination of nutrient restriction and Sorafenib significantly enhanced anti-tumor efficacy both in vivo and in vitro. Mechanistically, nutrient restriction potentiated Sorafenib-induced ferroptosis via the NRF2/HO-1/GPX4 pathway in HCC cells.
Authors
- Ke Chen (ORCID: https://orcid.org/0000-0002-8022-5837)
- Zhencang Zheng (ORCID: https://orcid.org/0000-0003-1183-4089)
- Tao Chen (ORCID: https://orcid.org/0000-0002-2334-3431)
- Kan Chen (ORCID: https://orcid.org/0000-0002-6822-6968)
- Zhengye Amelia Xu
- Kelin Shou
- Chong Jin
Institutions
- Zhejiang Sci-Tech University (CN)
- Taizhou Central Hospital (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jhc.s572919
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province