Profibrotic predictive toxicology in the lung
These findings demonstrate that mouse lung organoids effectively recapitulate key molecular and pathological aspects of drug- and toxin-induced pulmonary fibrosis and represent a powerful model for mechanistic investigation and preclinical screening of compounds with potential pro-fibrotic effects.
Authors
- Veena B. Antony (ORCID: https://orcid.org/0000-0002-2326-352X)
- Pooja Singh
- R. Sinha (ORCID: https://orcid.org/0000-0002-5869-0839)
Institutions
- University of Alabama at Birmingham (US)
- Pulmonary and Allergy Associates (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fphar.2026.1766054
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Environmental Health Sciences