Dynamic activation and dual roles of SOX9+ hepatocytes in liver regeneration under acute and chronic injury by single-cell transcriptomics
Our findings highlight SOX9<sup>+</sup> hepatocytes as a dynamic and context-dependent hepatocyte subpopulation associated with adaptive metabolic responses during regeneration and altered inflammatory and wound-healing-related programs under chronic injury.
Authors
- Junwei Zhang (ORCID: https://orcid.org/0000-0003-0486-8950)
- Yiyao Xu (ORCID: https://orcid.org/0000-0003-2393-1644)
- Xin Lu
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- University of Oxford (GB)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fcell.2026.1743286
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College