Synthesis of Spiro-Pyrazolone-Benzo[ <i>b</i> ]azepines via Three-Component [4 + 3] Annulation of Pyrazolone-Derived Azomethine Ylides with <i>N</i> -(2-Chloromethyl) Aryl Amides
A novel one-pot, three-component [4 + 3] annulation reaction of pyrazolone-derived azomethine ylides with <i>N</i>-(2-chloromethyl) aryl amides has been developed. This method provides efficient access to a series of interesting and valuable spiro-pyrazolone-benzo[<i>b</i>]azepines in moderate to excellent yields with high regioselectivity and excellent diastereoselectivity under mild conditions.
Authors
- Yulong Li (ORCID: https://orcid.org/0000-0001-5346-339X)
- Heng Yin
- Chenyi Li
- Jianming Xu
- Yao Wang
- Song Hu
- Dan Hu
- Jian Wang
Institutions
- Nankai University (CN)
- Institute of Catalysis and Petrochemistry (RU)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1021/acs.joc.5c02542
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00