Modulation of cortical functional connectivity and spectrum with transcranial focused ultrasound in chronic disorders of consciousness: a case report
This case provides cohesive, multi-modal evidence suggesting that targeted thalamic tFUS may be associated with a restorative process, concurrent with the normalization of dysfunctional cortical rhythms and the reintegration of large-scale brain networks that parallel the recovery of consciousness. Our findings offer preliminary insights supporting the continued investigation of tFUS as a potential therapeutic strategy for patients with severe brain injury.
Authors
- Kaixuan Luo (ORCID: https://orcid.org/0000-0003-1515-5737)
- Moxian Chen
- Xuan Xu
- Xiaojing Long (ORCID: https://orcid.org/0000-0003-4455-7831)
- Shu Cheng
- Lijuan Ao
- Lei Lei
- Xiangjun Feng
- Qihui Liang
- Fanyuan Meng
Institutions
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Kunming Medical University (CN)
- NIHR Oxford Musculoskeletal Biomedical Research Centre (GB)
- First Affiliated Hospital of Kunming Medical University (CN)
- Regenerative Medicine Institute (MX)
- National Rehabilitation Center (KR)
- Shenzhen Institutes of Advanced Technology (CN)
- Shanghai Sunshine Rehabilitation Center (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fpsyt.2026.1748927
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China