Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation
This study identified four novel ISR-related biomarkers for PAH and elucidated their roles in immune infiltration and cellular remodeling. The findings provided new insights into PAH pathogenesis and offered potential tools for diagnosis and targeted therapy.
Authors
- Chenming Qiu (ORCID: https://orcid.org/0000-0003-1124-3721)
- Haoran Li (ORCID: https://orcid.org/0009-0005-2375-9188)
- Yongjian Yang (ORCID: https://orcid.org/0000-0003-1268-166X)
- Cong Lan
- Meiling Li
Institutions
- Command Hospital (IN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Clinical and Experimental Hypertension
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1080/10641963.2026.2629926
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00