Predicting drug–drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling
The findings suggest a clinically relevant interaction between ayahuasca and SSRIs, as even modest increases in DMT exposure may intensify serotonergic effects in individuals receiving antidepressant therapy. This study provides a mechanistic and quantitative framework for assessing interaction risks between ayahuasca alkaloids and SSRIs, supporting clinical decision-making and harm-reduction strategies in contexts where controlled drug-drug interaction studies are not feasible.
Authors
- Tânia Marcourakis (ORCID: https://orcid.org/0000-0002-0076-5017)
- Fabiane Dörr (ORCID: https://orcid.org/0000-0002-6077-1814)
- José Augusto Silva Reis (ORCID: https://orcid.org/0009-0005-5397-4751)
- Adrieli Oliveira Raminelli (ORCID: https://orcid.org/0000-0002-3890-7535)
- Frederico Severino Martins (ORCID: https://orcid.org/0000-0001-5555-8771)
- Lorena Terene Lopes Guerra
- Rafael G. dos Santos (ORCID: https://orcid.org/0000-0003-2388-4745)
- Bianca Villanova
- Beatriz Aparecida Passos Bismara Paranhos
- Caio Cesar de Paula
- Maurício Yonamine
- Gabriella de Souza Gomes Ribeiro
- Jaime Eduardo Cecílio Hallak
- Anna Beatriz Vicentini Zacharias
Institutions
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fmolb.2026.1768402
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior