Identification of immune-mediated aging genes associated with cervical spondylosis through single-cell eQTL Mendelian randomization

This study reveals immune cell-specific genetic regulators linking immune aging to cervical spondylosis and identifies 5-ASA as a candidate therapeutic agent. Our single-cell MR framework offers novel insights into immunogenetic mechanisms driving age-related spinal degeneration and highlights actionable targets for translational research.