Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta‐analysis
A meta-analysis across three independent cohorts shows that female cognitive advantage at low tau shifts to vulnerability at higher tau. Sex differences in tau-related cognitive decline were consistent after accounting for amyloid burden. Sex-specific rates of cognitive decline should be considered in clinical trial design.
Authors
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Emilie T. Reas (ORCID: https://orcid.org/0000-0002-4110-5154)
- Hannah M Klinger
- Hyun‐Sik Yang
- Colin Birkenbihl
- Jane A. Brown
- A. Li
- Rebecca E. Langhough
- the A4 Study Team
- Aaron P. Schultz
- Keith A. Johnson
- Madison Cuppels
- Robert A. Rissman
- Michelle Farrell
- Dorene M. Rentz
- Reisa A. Sperling
- Michael J. Properzi
- Mabel Seto
- Diana L. Townsend
- Kathryn V. Papp
- Michael C. Donohue
- Sterling C. Johnson
- Rebecca E. Amariglio
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Autism Research Institute (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- The University of Melbourne (AU)
- Massachusetts General Hospital (US)
- Australian Psychological Society (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71031
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Eli Lilly and Company
- GHR Foundation
- National Institutes of Health
- National Institute on Aging