Efficacy of Probiotic Escherichia coli Nissle 1917 in Counteracting Reserpine-induced Depression-like Symptoms and Neuroinflammation in Zebrafish

EcN significantly attenuated reserpine-induced depression-like behavior, oxidative stress, neuronal damage, and neuroinflammation in adult zebrafish, as evidenced by statistically significant improvements in behavioral, biochemical, and inflammatory endpoints. These findings support EcN as a promising psychobiotic with antidepressant-like properties, warranting further mechanistic and translational investigations.