Development of a Current Good Manufacturing Practice–Compliant Process for Producing <i>Cryptosporidium parvum</i> Oocysts for Clinical Use
We describe a robust cGMP-compliant and qualification process for C. parvum oocysts that enables CHIM studies in healthy adults. Thereby opening avenues to evaluate efficacy of novel therapeutics and vaccines to treat cryptosporidiosis.
Authors
- Christopher D. Huston (ORCID: https://orcid.org/0000-0002-5393-139X)
- Natko Nuber
- Zachary Thompson (ORCID: https://orcid.org/0009-0006-5654-8915)
- Lucy C. Watson (ORCID: https://orcid.org/0009-0000-1907-768X)
- Suresh B. Lakshminarayana (ORCID: https://orcid.org/0000-0002-9133-3147)
- Ujjini H. Manjunatha (ORCID: https://orcid.org/0000-0002-7461-9303)
- Johanne Blais (ORCID: https://orcid.org/0000-0001-8139-8855)
- Michael W. Riggs (ORCID: https://orcid.org/0000-0001-6207-6543)
- Thierry T. Diagana (ORCID: https://orcid.org/0000-0002-8520-5683)
- Mark R. Jones (ORCID: https://orcid.org/0000-0002-4781-2167)
- Jay Lakshman
- Juergen Dederichs
- Dean Wetty
- Christian Ostermeier
- Bryanna Thomas (ORCID: https://orcid.org/0009-0001-4809-3969)
- Deborah A. Schaefer (ORCID: https://orcid.org/0000-0003-2797-0499)
- Sofia Braud-Perez
- Slobodan Grubesic
- Joseph Etse
- Lizhuo Nouaime
- Rajiv S Jumani
- Juergen Hubert Blusch
- Tareq Z Jaber
Institutions
- University of Vermont (US)
- Novartis (Switzerland) (CH)
- Charles River Laboratories (Netherlands) (NL)
- University of Arizona (US)
- Novant Health (US)
- Charles River Laboratories (United States) (US)
- Tris Pharma (United States) (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1093/infdis/jiag107
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00