MiR-135b-5p relieves sevoflurane-induced postoperative cognitive dysfunction by inhibiting JAK2–STAT3-mediated hepcidin upregulation
Our findings suggest that miR-135b-5p attenuates sevoflurane-induced POCD in mice by suppressing hepcidin expression through inhibition of the JAK2-STAT3 pathway, indicating a potential therapeutic approach for sevoflurane-induced POCD.
Authors
- Jin-Meng Kang
- Fenghui Guo
- Tian Xie (ORCID: https://orcid.org/0000-0003-3222-3260)
- Hong-meng Xu
- Yu-hua Liu
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.brainresbull.2026.111785
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00