Integrating machine learning and Mendelian randomization for identifying genetic biomarkers in bladder cancer: implications for early diagnosis and targeted therapies

This study demonstrates the power of combining machine learning and MR to uncover genetic biomarkers for BC. FAM107A emerges as a promising diagnostic and therapeutic target, offering new insights for personalized BC treatment strategies.

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Publication Details

Journal
International Journal of Surgery
Published
2025-12-03
DOI
https://doi.org/10.1097/js9.0000000000003833
Primary Topic
Bladder and Urothelial Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrating machine learning and Mendelian randomization for identifying genetic biomarkers in bladder cancer: implications for early diagnosis and targeted therapies

Chaojie Xu, Yuchen Liu, C Zhang, Changning Lv et al.
International Journal of Surgery
Bladder and Urothelial Cancer Treatments
article

Integrating machine learning and Mendelian randomization for identifying genetic biomarkers in bladder cancer: implications for early diagnosis and targeted therapies

Chaojie Xu, Yuchen Liu, C Zhang, Changning Lv, Chen Li, Jiou Li, Lin Yao, Ying Dong, Liqun Zhou
article en

Abstract

This study demonstrates the power of combining machine learning and MR to uncover genetic biomarkers for BC. FAM107A emerges as a promising diagnostic and therapeutic target, offering new insights for personalized BC treatment strategies.

International Journal of SurgeryVol. 112(2)
Guangxi Medical University (CN), Peking University (CN), First Affiliated Hospital of GuangXi Medical University (CN), Peking University First Hospital (CN), Shenzhen University Health Science Center (CN), Shenzhen Institutes of Advanced Technology (CN), Shenzhen Second People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 22%
Bladder and Urothelial Cancer Treatments
DOIOpen Access PDFOpenAlex
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Integrating machine learning and Mendelian randomization for identifying genetic biomarkers in bladder cancer: implications for early diagnosis and targeted therapies — Chaojie Xu, Yuchen Liu, et al. · International Journal of Surgery (2025) | TGRS Research Map | TGRS