Endogenous DNA Damage and Its Role in Human Disease

Endogenous DNA damage from metabolism and genome dynamics drives mutation, instability, and disease. New insights from ACS Fall 2025 reveal chemical diversity, metabolic drivers, and repair limits that shape cancer risk and biomarker development.

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Publication Details

Journal
Chemical Research in Toxicology
Published
2026-02-18
DOI
https://doi.org/10.1021/acs.chemrestox.5c00539
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Endogenous DNA Damage and Its Role in Human Disease

Clare Lauderback, Eva-Maria Bryan
Chemical Research in Toxicology
DNA Repair Mechanisms
article

Endogenous DNA Damage and Its Role in Human Disease

Clare Lauderback, Eva-Maria Bryan
article en

Abstract

Endogenous DNA damage from metabolism and genome dynamics drives mutation, instability, and disease. New insights from ACS Fall 2025 reveal chemical diversity, metabolic drivers, and repair limits that shape cancer risk and biomarker development.

Chemical Research in Toxicology
George Mason University (US), Institute for Advanced Medical Research (US)
Good health and well-being
Openalex Percentile: Top 52%
DNA Repair Mechanisms
DOIOpen Access PDFOpenAlex
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Endogenous DNA Damage and Its Role in Human Disease — Clare Lauderback, Eva-Maria Bryan · Chemical Research in Toxicology (2026) | TGRS Research Map | TGRS