<scp>CSF</scp> ‐Compartmentalized Antibody Glycoprofiles in <scp>NMDAR</scp> Encephalitis Associate with Etiology and Functional Recovery
In NMDARe, CSF Fc-glycosylation profiles are both compartment- and trigger-specific. Because glycan signatures shape innate immune interactions (e.g., with NK cells), these findings highlight distinct pathogenic mechanisms and support Fc-glycosylation profiling as a potential prognostic biomarker. ANN NEUROL 2026.
Authors
- Eugenia Martínez‐Hernández (ORCID: https://orcid.org/0000-0002-8317-7068)
- Elianet Fonseca (ORCID: https://orcid.org/0000-0002-3613-3185)
- Estibaliz Maudes (ORCID: https://orcid.org/0000-0003-1723-042X)
- Takahiro Iizuka (ORCID: https://orcid.org/0000-0002-7234-0720)
- Marianna Spatola (ORCID: https://orcid.org/0000-0003-2548-0429)
- Chiara Milano
- Laura Marmolejo (ORCID: https://orcid.org/0000-0003-2385-5370)
- Ivana Duvnjak Orešković (ORCID: https://orcid.org/0009-0000-4807-8913)
- Thaís Armangue
- Helena Ariño
- Gemma Olivé‐Cirera
- Maja Pučić‐Baković
- Esther Aguilar
- Claudia Papi
- Mar Guasp
- Josep Dalmau
- Jerko Štambuk
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- Universitat Autònoma de Barcelona (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Hospital de Sant Pau (ES)
- Centro de Investigación Biomédica en Red (ES)
- Genos (Croatia) (HR)
- Vall d'Hebron Hospital Universitari (ES)
- ERN GUARD-Heart (NL)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Kitasato University (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1002/ana.78175
- Citations
- 1
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- “la Caixa” Foundation
- European Commission
- Generalitat de Catalunya
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- European Regional Development Fund
- Departament de Salut, Generalitat de Catalunya
- European Social Fund