<scp>SGLT2</scp> Inhibitor‐Associated Changes in Urinary Volatile Organic Compounds in Diabetic Kidney Disease: A Comprehensive Study
Our findings indicate that SGLT2 inhibitor therapy is associated with elevated urinary ketone-related VOCs, reflecting a shift in systemic energy metabolism. These observations contribute to a better understanding of the metabolic mechanisms underlying the kidney-protective effects of SGLT2 inhibitors. Considering that urinary VOCs can be measured non-invasively, this approach holds promise for future research and clinical monitoring of treatment effects in DKD.
Authors
- Toyohiro Hashiba (ORCID: https://orcid.org/0000-0002-9755-0935)
- Huang Keying
- Yosuke Hirakawa
- Risa Hara (ORCID: https://orcid.org/0000-0003-0529-651X)
- Hitoshi Tabata (ORCID: https://orcid.org/0000-0001-5048-6385)
- Hiroyasu Yamahara (ORCID: https://orcid.org/0000-0003-2369-5813)
Institutions
- The University of Tokyo (JP)
Publication Details
- Journal
- Nephrology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/nep.70176
- Primary Topic
- Advanced Chemical Sensor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Daiichi-Sankyo
- University of Tokyo
- Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering