ScRNA-seq reveals dynamic macrophage heterogeneity in chronic liver disease progression and prognostic biomarkers KLF2/SPP1 in HCC
We provided a stage-resolved framework to delineated macrophage heterogeneity during CLDs progression and identified SPP1 and KLF2 as candidate prognostic biomarkers and potential therapeutic targets in HCC.
Authors
- Xinru Wang
- Qi Pan (ORCID: https://orcid.org/0000-0002-1852-1387)
- Xuenan Yuan
- Jie Yang (ORCID: https://orcid.org/0000-0003-4346-9100)
- Borui Li (ORCID: https://orcid.org/0009-0007-6637-8523)
- Zhihong Zhang
- An-Yuan Guo
- Shuwen Chen
- Jiahong Hu
- Zhenzhen Cai
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Wuhan National Laboratory for Optoelectronics (CN)
- Health & Life (Taiwan) (TW)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1766301
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hainan University
- Wuhan National Laboratory for Optoelectronics