Denosumab in pediatric patients with fibrous dysplasia/McCune-Albright syndrome: a single-center, open-labeled study

Denosumab appears to be effective in pediatric FD/MAS patients, however safety concerns remain. Comprehensive pre-treatment evaluation and close monitoring throughout the treatment course are essential. Further prospective studies and randomized controlled trials are needed to determine optimal dosing strategies and establish long-term safety in this population.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-02-18
DOI
https://doi.org/10.3389/fendo.2026.1762370
Primary Topic
Bone Tumor Diagnosis and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Denosumab in pediatric patients with fibrous dysplasia/McCune-Albright syndrome: a single-center, open-labeled study

W. Qi, Qianqian Pang, Li Mei, Ruizhi Jiajue et al.
Frontiers in Endocrinology
Bone Tumor Diagnosis and Treatments
article

Denosumab in pediatric patients with fibrous dysplasia/McCune-Albright syndrome: a single-center, open-labeled study

W. Qi, Qianqian Pang, Li Mei, Ruizhi Jiajue, Ruotong Zhou, Yiyi Gong, Lijia Cui, Yan Jiang, Weibo Xia, Xiaoping Xing, Xiang Li, Ou Wang, Yue Chi, Quanshi Ouyang, Wei Liu
article en

Abstract

Denosumab appears to be effective in pediatric FD/MAS patients, however safety concerns remain. Comprehensive pre-treatment evaluation and close monitoring throughout the treatment course are essential. Further prospective studies and randomized controlled trials are needed to determine optimal dosing strategies and establish long-term safety in this population.

Frontiers in EndocrinologyVol. 17
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN)
National Natural Science Foundation of China, Peking Union Medical College Hospital, National Science and Technology Major Project
Openalex Percentile: Top 53%
Bone Tumor Diagnosis and Treatments
DOIOpen Access PDFOpenAlex
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Denosumab in pediatric patients with fibrous dysplasia/McCune-Albright syndrome: a single-center, open-labeled study — W. Qi, Qianqian Pang, et al. · Frontiers in Endocrinology (2026) | TGRS Research Map | TGRS