Chromatin Engagement and Transcriptional Activity of the ZNF217 Exon 4–Skipping Isoform Are Associated with Breast Cancer Aggressiveness and Bone Metastasis
Overall, this study identifies ZNF217-ΔE4 as a novel functional isoform that mediates breast cancer cell aggressiveness and bone marrow homing. It also highlights this isoform as a promising biomarker and potential therapeutic target for breast cancers at elevated risk of bone metastasis.
Authors
- Martine Croset (ORCID: https://orcid.org/0000-0003-0564-7033)
- Philippe Clézardin (ORCID: https://orcid.org/0000-0003-0149-4463)
- L. Bouazza
- Séverine Croze
- Joël LACHUER
- Farah Ramadan (ORCID: https://orcid.org/0000-0002-1171-0396)
- Pascale A. Cohen (ORCID: https://orcid.org/0000-0001-7016-9598)
- Pia Fahmé
- Mariapia Riso
- Balázs Győrffy
- Olivier Peyruchaud
- Robert A. Coleman
- Justin Ferraro
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Semmelweis University (HU)
- Centre National de la Recherche Scientifique (FR)
- Albert Einstein College of Medicine (US)
- Inserm (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Physiopathologie, diagnostic et traitements des maladies musculo-squelettiques (FR)
- University of Pecs (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3390/cancers18040664
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00