Large B-Cell Lymphoma Invading the Heart

We report a case of a young woman who presented with a rapidly growing and aggressive diffuse large B-cell lymphoma with mediastinal and myocardial infiltration and involvement of the pulmonary trunk and coronary arteries. A noninvasive multimodality imaging assessment was performed with transthoracic echocardiography, computed tomography, and cardiac magnetic resonance. Although this approach may allow for a precise and timely characterization of myocardial infiltration and thus demonstrate therapeutic implications, large B-cell lymphoma has been rarely documented using contemporary multimodality imaging techniques. This report underscores the value of a multimodality diagnostic strategy, illustrating the incremental contribution of each routinely available imaging modality to achieve prompt diagnosis and optimize patient management.