Causal role of genetically predicted impairment of branched‐chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes
Our genetic analysis indicates BCAA catabolism and insulin secretion/action interact with each other; their aberrance might form a vicious cycle promoting T2D progression.
Authors
- Jiawen Lu (ORCID: https://orcid.org/0000-0003-2671-3028)
- Zhenqian Wang
- Gloria Hoi‐Yee Li (ORCID: https://orcid.org/0000-0003-0275-2356)
- Xiangyu Zhou
- Kenneth King‐Yip Cheng
Institutions
- Hong Kong Polytechnic University (HK)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1111/dom.70565
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research Grants Council, University Grants Committee
- Hong Kong Polytechnic University