Bridging Metabolomics and Nociception: The Arachidonic Acid–NMDA Receptor Axis in Burning Mouth Syndrome

The Arachidonic Acid (AA)-NMDA Receptor Axis describes a crucial neurochemical pathway where glutamate activation of NMDA receptors releases AA. AA binds directly to NMDA receptor subunits, increasing their open probability and also affecting other receptors and cellular processes, linking neuronal activity to lipid signalling.

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Publication Details

Journal
Journal of Oral Rehabilitation
Published
2026-02-18
DOI
https://doi.org/10.1111/joor.70171
Primary Topic
Salivary Gland Disorders and Functions
Type
article
Field-Weighted Citation Impact
0.00
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article

Bridging Metabolomics and Nociception: The Arachidonic Acid–NMDA Receptor Axis in Burning Mouth Syndrome

Takahiko Nagamine
Journal of Oral Rehabilitation
Salivary Gland Disorders and Functions
article

Bridging Metabolomics and Nociception: The Arachidonic Acid–NMDA Receptor Axis in Burning Mouth Syndrome

Takahiko Nagamine
article en

Abstract

The Arachidonic Acid (AA)-NMDA Receptor Axis describes a crucial neurochemical pathway where glutamate activation of NMDA receptors releases AA. AA binds directly to NMDA receptor subunits, increasing their open probability and also affecting other receptors and cellular processes, linking neuronal activity to lipid signalling.

Journal of Oral Rehabilitation
Tokyo Medical and Dental University (JP), nLIGHT (United States) (US)
Openalex Percentile: Top 50%
Salivary Gland Disorders and Functions
DOIOpen Access PDFOpenAlex
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Bridging Metabolomics and Nociception: The Arachidonic Acid–NMDA Receptor Axis in Burning Mouth Syndrome — Takahiko Nagamine · Journal of Oral Rehabilitation (2026) | TGRS Research Map | TGRS