Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis
These findings establish progressive ET depletion as a hallmark of obesity-induced testicular dysfunction and demonstrate that ET supplementation restores steroidogenesis and mitochondrial redox homeostasis, providing a robust mechanistic basis for antioxidant-guided interventions in male infertility.
Authors
- Man Wu (ORCID: https://orcid.org/0009-0006-0714-3647)
- Hongfei Ke
- Xin Fu (ORCID: https://orcid.org/0000-0001-9726-9388)
- Yu Lan
- Jiajing Lin
- Xiaomin Li (ORCID: https://orcid.org/0009-0009-7903-8282)
- You Che
- Feixue Han
- Geng An
- Zhiying Huang
- Zhicong Chen
- Tianwen Peng
- Shuyan Chen
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- HKU-Pasteur Research Pole (HK)
- The First People's Hospital of Zhaoqing (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.redox.2026.104090
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00