Identification of public neoantigens with broad HLA class I coverage as candidates for off-the-shelf cancer vaccine development in colorectal cancer
These findings identify TP53_R273H as a clinically relevant shared neoantigen in CRC and support the translational feasibility of a population-tailored OTS neoantigen panel. Our integrative computational and experimental framework highlights the importance of combining population-level HLA coverage with functional validation to advance broadly applicable neoantigen-based immunotherapies.
Authors
- Hoa Giang
- Bui Que Tran Nguyen
- Hoai Nghia Nguyen
- Thanh Sang Tran
- Le Son Tran
- Minh-Duy Phan
- Duc Huy Tran
- Thi Kim Cuong Ho
- Thanh Nhan Nguyen
- Minh-Triet Le
- Dinh Viet Linh Nguyen
- Thi Mong Quynh Pham
- Diem TP Tran
- Truong-Vinh Ngoc Pham
- Vy Nguyen
- Pham Trung Dung Nguyen
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ho Chi Minh City University of Science (VN)
- University Medical Center HCMC (VN)
- Genomic and Immunotherapy Medical Institute (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1686224
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00