Free fatty acid receptor 2 allosterism is defined by cellular context
Across systems, Ca²⁺ mobilization emerged as a conserved, receptor-proximal output of FFA2R, while allosteric modulation by Cmp58 and AZ1729 promoted Gα<sub>i/o</sub>-biased signaling that enabled ROS generation. These data define pathway-selective allosterism at FFA2R and highlight Ca²⁺ mobilization and ROS as informative readouts for therapeutic strategies that exploit allosteric control.
Authors
- Linda C. Johansson (ORCID: https://orcid.org/0000-0003-4776-5142)
- Claes Dahlgren
- Sarah Al Hamoud Al Asswad
- Ayaan Abdi Ali
- Simon Lind
- Volker M. Lauschke
Institutions
- Central South University (CN)
- Karolinska Institutet (SE)
- Institute for Biomedicine (IT)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Second Xiangya Hospital of Central South University (CN)
- University of Tübingen (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1186/s12964-026-02730-5
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00