U-shaped association of the non-HDL/HDL ratio with cognitive impairment identified by conventional analyses and machine learning in health examination participants in Liuyang

In this cross-sectional analysis, NHHR was associated with cognitive impairment in a U-shaped pattern and demonstrated better discrimination than individual lipid measures. These findings suggest that NHHR may serve as an alternative lipid-related index in studies of cognitive health, although longitudinal studies are needed to clarify its predictive value.