Zuoguiyin modulates M2 macrophage polarization to inhibit glycolysis in esophageal squamous cell carcinoma
This study elucidates the mechanism through which IL-4/JAK2/STAT6-mediated M2 macrophages promote glycolysis in ESCC and demonstrates that ZGY disrupts this pathway by targeting JAK2 in macrophages. These findings provide a mechanistic foundation for developing ZGY as a promising tumor microenvironment-modifying therapy for ESCC.
Authors
- Tiantian Xing
- Jianxin Guo (ORCID: https://orcid.org/0009-0008-7599-4149)
- Yuxing Wang (ORCID: https://orcid.org/0000-0003-3079-5572)
- Jianfeng Yuan
- Ming Huang
- Lu Zhou
- Zhongbing Wu
- Ruixue Huang
- Jing Li
- Liping Chang
Institutions
- Hebei Medical University (CN)
- Shijiazhuang University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.jep.2026.121404
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00