Validation of CURB-65, CRB-65, NEWS2, qSOFA, and 4C scores for predicting mortality in COVID-19 patients across seven emergency Departments in Colombia

The 4C Mortality Score outperformed other models in predicting COVID-19 mortality. Its use in emergency settings alongside clinical judgment can enhance risk stratification, guide hospitalization decisions, and optimize resource allocation. Recalibration and decision analysis are essential for its clinical applicability. Further validation with contemporary data is essential to ensure its transportability across epidemiological settings.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-02-18
DOI
https://doi.org/10.3389/fmed.2026.1738978
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Validation of CURB-65, CRB-65, NEWS2, qSOFA, and 4C scores for predicting mortality in COVID-19 patients across seven emergency Departments in Colombia

María Lucia Mesa-Rubio, Julio Alberto Chacón Sarmiento, Juliana Cuervo-Rojas, Paola Rengifo et al.
Frontiers in Medicine
Sepsis Diagnosis and Treatment
article

Validation of CURB-65, CRB-65, NEWS2, qSOFA, and 4C scores for predicting mortality in COVID-19 patients across seven emergency Departments in Colombia

María Lucia Mesa-Rubio, Julio Alberto Chacón Sarmiento, Juliana Cuervo-Rojas, Paola Rengifo, Oscar C. Muñoz, Roberto Tarud Ayub, Ilich Herbert De la Hoz Siegler, Mónica Padilla, Janet Dı́az, Ginna Tambini, José Antonio Rojas, Samuel Martínez-Vernaza, Carlos Álvarez, Sandra Patiño, Claudia Aristizabal, Alejandra Cañas-Arboleda, Ludovic Reveiz, Sandra Liliana Valderrama-Beltran, Martín Rondón, Alfonso J. Rodriguez-Morales, Jaime Villa, Silvia Bertagnolio, Juan Sebastián Bravo Ojeda
article en

Abstract

The 4C Mortality Score outperformed other models in predicting COVID-19 mortality. Its use in emergency settings alongside clinical judgment can enhance risk stratification, guide hospitalization decisions, and optimize resource allocation. Recalibration and decision analysis are essential for its clinical applicability. Further validation with contemporary data is essential to ensure its transportability across epidemiological settings.

Frontiers in MedicineVol. 13
Universidad Iberoamericana (MX), Pontificia Universidad Javeriana (CO), Universidad Científica del Sur (PE), Universidad Nacional de Colombia (CO), Hospital Carmen y Severo Ochoa (ES), Clínica Santa María (CO), Hospital Universitario Reina Sofía (ES), Hospital Universitario San Ignacio (CO), Institución Universitaria Visión de las Américas (CO), Fundación Universitaria Sanitas (CO), Pan American Health Organization (Cuba) (CU), Ibero-American University Puebla (MX)
Peace, Justice and strong institutions
Openalex Percentile: Top 51%
Sepsis Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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