Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy

All INSTI-based regimens led to immune restoration, but modest differences in biomarker trajectories suggest distinct immunomodulatory effects. The clinical relevance of these differences remains unclear and warrants further study to assess their role in long-term comorbidity risk.

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Publication Details

Journal
PLoS ONE
Published
2026-02-18
DOI
https://doi.org/10.1371/journal.pone.0343230
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy

Francisca Artigues, Fernando Dronda, Mariano Matarranz del Amo, Nisa Boukichou-Abdelkader et al.
PLoS ONE
HIV-related health complications and treatments
article

Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy

Francisca Artigues, Fernando Dronda, Mariano Matarranz del Amo, Nisa Boukichou-Abdelkader, Ramón Morillo, CoRIS cohort, Enrique Bernal, Arkaitz Imaz, Sergio Padilla, Joaquim Peraire, María-Jesús Bustinduy-Odriozola, María Saumoy, Antonia Alcaraz, Alberto Delgado
article en

Abstract

All INSTI-based regimens led to immune restoration, but modest differences in biomarker trajectories suggest distinct immunomodulatory effects. The clinical relevance of these differences remains unclear and warrants further study to assess their role in long-term comorbidity risk.

PLoS ONEVol. 21(2)
Universitat de Miguel Hernández d'Elx (ES), Bellvitge University Hospital (ES), Hospital Costa del Sol (ES), Hospital Universitario de Guadalajara (ES), Hospital Reina Sofía de Murcia (ES), Hospital San Pedro (ES), Donostiako Unibertsitate Ospitalea (ES), Center for Biomedical Research of La Rioja (ES), Servicio de Salud de Castilla La Mancha (ES), Hospital Universitario Virgen de la Arrixaca (ES), Hospital Universitari Joan XXIII de Tarragona (ES), Hospital Universitario Son Espases (ES), Hospital Universitario Ramón y Cajal (ES), Hospital Universitario Infanta Leonor (ES)
Good health and well-being
Openalex Percentile: Top 55%
HIV-related health complications and treatments
DOIOpen Access PDFOpenAlex
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Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy — Francisca Artigues, Fernando Dronda, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS