Detection of cell impurities and NF-κB activation using SEAP reporter cell lines in vaccines
This assay enables manufacturers and regulators to meet the growing demand for reliable impurity screening assays that support the characterization of vaccines activating the NF-κB pathway. Future studies must further characterise NF-κB activation by individual TLRs across a broader range of vaccines.
Authors
- Vidyani Manatunga
- Pearl Bamford
- Sarah Mercier
- Georgia Gilmayer
- Anita Carscadden
- Laura McMahon
- Jackson Williams
- Jodie Latta
- Lisa Kerr
Institutions
- Department of Health and Aged Care (AU)
- Act Health (AU)
Publication Details
- Journal
- Journal of Virological Methods
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.jviromet.2026.115375
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00