Sticky memories of an activated macrophage
Innate immune cells can retain molecular imprints of past encounters long after the initial stimulus has ceased. In this issue, Gorin et al. (https://doi.org/10.1084/jem.20250976) reveal an unexpected mechanism by which IFN-γ sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface.
Authors
- Renato Ostuni (ORCID: https://orcid.org/0000-0003-0460-3426)
- Luca Frosio
Institutions
- Vita-Salute San Raffaele University (IT)
- The San Raffaele Telethon Institute for Gene Therapy (IT)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1084/jem.20252624
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00