Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair
The combination medication enhanced apoptotic sensitivity in endometriosis by restoring p53 activity through targeting hormonal signalling and DNA repair pathways. This strategy offered strong potential for clinical translation.
Authors
- Huidi Jiang
- Dongli Sun
- Jingjing Yan (ORCID: https://orcid.org/0009-0001-1207-1290)
- Wenqiang Qian (ORCID: https://orcid.org/0009-0000-7726-9495)
- Yujie Peng
- Yu Xin
- Weidong Fei
- Meng Zhang
- Mengdan Zhao
- Libo Zhu
Institutions
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Zhejiang Pharmaceutical College (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1111/bph.70360
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00