The role of IGF1 signaling in remote ischemic conditioning-mediated amelioration of Alzheimer's disease pathology and cerebral insulin resistance
Findings show that RIC effectively inhibits CIR by enhancing the IGF1R/IRS1-AKT-GSK3β pathway and glucose-mitochondrial energy metabolism. This study identifies a novel RIC neuroprotective mechanism, offering a multi-target AD prevention/treatment strategy.
Authors
- Fujia Gao
- Haoran Ma
- Tao Yuan
- Wuxiang Sun
- Jiayu Li
- Yuxuan Ma
- Sihan Guo
- Xin Zhang
- Jiaxin An
- Ruimin Wang
- Jing Bai
Institutions
- North China University of Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.expneurol.2026.115685
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00