Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an <scp> F <sub>1</sub> </scp> Generation of Mice

The dose levels of DIN with PBO in the present study affected exploratory and spontaneous behavior at lower dose levels than those observed in previous studies with the single administration of DIN and PBO. Therefore, the dose level of PBO (0.03%, approximately 44-116 mg/kg body weight/day) is estimated to have a synergistic effect on DIN exposure.

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Publication Details

Journal
Birth Defects Research
Published
2026-02-01
DOI
https://doi.org/10.1002/bdr2.70035
Primary Topic
Insect and Pesticide Research
Type
article
Field-Weighted Citation Impact
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article

Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an F 1 Generation of Mice

Toyohito Tanaka, Akiko Inomata
Birth Defects Research
Insect and Pesticide Research
article

Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an F 1 Generation of Mice

Toyohito Tanaka, Akiko Inomata
article en

Abstract

The dose levels of DIN with PBO in the present study affected exploratory and spontaneous behavior at lower dose levels than those observed in previous studies with the single administration of DIN and PBO. Therefore, the dose level of PBO (0.03%, approximately 44-116 mg/kg body weight/day) is estimated to have a synergistic effect on DIN exposure.

Birth Defects ResearchVol. 118(2)
Tokyo Metropolitan Institute of Public Health (JP)
Openalex Percentile: Top 57%
Insect and Pesticide Research
DOISourceOpenAlex
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Reproductive and Neurobehavioral Effects of Combined Exposure to Dinotefuran and Piperonyl Butoxide in an <scp> F <sub>1</sub> </scp> Generation of Mice — Toyohito Tanaka, Akiko Inomata · Birth Defects Research (2026) | TGRS Research Map | TGRS