Influence of Propofol-Induced Sedation on White Matter Functional Connectivity
Propofol disrupts white matter functional connectivity, with deep sedation inducing widespread functional connectivity reductions, particularly in key tracts and networks. The disruption of white matter functional connectivity may reflect a breakdown in large-scale brain integration and could serve as a biomarker for deep propofol-induced sedation, although not necessarily its mechanistic driver.
Authors
- Minyu Jian
- Haiyang Liu (ORCID: https://orcid.org/0000-0002-8434-0349)
- Ruquan Han
- Leqing Zhou
- Yong Liu
- Jiayi Zhang
- Di Zhang
- Fangrong Zong
Institutions
- Beijing University of Posts and Telecommunications (CN)
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1213/ane.0000000000007975
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00