Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers

Severe mental disorders have strong associations with metabolites, and MDD has a distinctly different genetic relationship than bipolar disorder and schizophrenia do. The study findings suggest that metabolic pathways are involved in the development of severe mental disorders and can play a central role in disentangling disorder-specific etiologies. The "metabolic psychiatry" approach applied here has high potential to guide development of targeted interventions.