Albumin-bound paclitaxel drives a cytotoxic CD8+ T cell enriched immune microenvironment in triple negative breast cancer
Our study indicate that, beyond its direct cytotoxic effects, nab-PTX may exert anti-tumor activity in TNBC through modulation of the tumor immune microenvironment. By inducing ICD and promoting DCs activation, nab-PTX appears to support CD8<sup>+</sup> T cell recruitment, thereby potentially enhancing immune mediated tumor regression. This immunologically supportive role of nab-PTX highlights its potential value in strategies aimed at improving the efficacy of chemotherapy based or immunotherapy combined treatments in TNBC.
Authors
- Daohong Li
- Zuquan Hu
- Xianlin Zeng (ORCID: https://orcid.org/0000-0001-8243-9663)
- Wei Xiong
- Xianhuai Jin
- Shuai Zhang
- Yan Luo
- Daiqin Luo
- Jinhua Long
- Zhu Zeng
Institutions
- Guiyang Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Guizhou Center for Disease Control and Prevention (CN)
- Ministry of Education (RO)
- Key Laboratory of Guangdong Province (CN)
- Guizhou Cancer Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Cellular Therapeutics (United Kingdom) (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1765165
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00