Comparative safety profiles of risankizumab versus guselkumab: a pharmacovigilance study based on the FAERS database

Guselkumab and risankizumab exhibit divergent real-world safety profiles, challenging the notion of a uniform class effect. Clinicians should be vigilant for malignancies and serious systemic events with risankizumab, particularly in the elderly, while prioritizing patient education for guselkumab to prevent administration errors. These findings support individualized treatment strategies to minimize drug-specific risks.