Risk Factors for Immunological Sensitization to <i>Mycobacterium tuberculosi</i> s and Progression to Incident TB Disease Among HIV-uninfected Adults in a High Burden Setting
Mtb-sensitized individuals had a three-fold higher risk of prevalent TB and progressing to TB compared to Mtb-unsensitized individuals. In high-prevalence settings, identifying individuals at greatest risk-such as those recently infected, with a history of smoking, or low BMI-could help refine TB prevention efforts and reduce community-level transmission.
Authors
- Gerhard Walzl (ORCID: https://orcid.org/0000-0003-2487-125X)
- Gavin Churchyard (ORCID: https://orcid.org/0000-0002-4269-3699)
- Michèle Tameris (ORCID: https://orcid.org/0000-0002-7983-7203)
- Munyaradzi Musvosvi (ORCID: https://orcid.org/0000-0002-4526-8479)
- Mark Hatherill
- Adam Penn-Nicholson
- Kogieleum Naidoo
- Andrew Fiore-Gartland
- Humphrey Mulenga
- Thomas J Scriba
- Simon C Mendelsohn
Institutions
- University of the Witwatersrand (ZA)
- Vanderbilt University (US)
- Stellenbosch University (ZA)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Fred Hutch Cancer Center (US)
- South African Tuberculosis Vaccine Initiative (ZA)
- Aurum Institute (ZA)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1093/infdis/jiag100
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00