Polyphyllin <scp>VII</scp> Alleviates Rheumatoid Arthritis by Reducing Oxidative Stress and Inflammation Through Downregulation of Ribonucleotide Reductase Regulatory Subunit <scp>M2</scp> Expression
Our results showed that PP7 exerted anti-RA activity through inhibition of oxidative stress and inflammatory responses via modulating RRM2 expression. These findings provided evidence that PP7 might be a promising agent for the treatment of RA.
Authors
- Xiaodan Chen
- Qiaoping Wu (ORCID: https://orcid.org/0000-0002-8796-2952)
- Chunyan You
- Guangliang Wu
- Jiliang Yan
- Jia Xu
- Pei Zhang
Institutions
- Ningbo No. 2 Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Phytotherapy Research
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1002/ptr.70271
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00