Anti-MDA5 monoclonal antibodies from patients with dermatomyositis – B cell characteristics and differential targeting of the helicase domains
Our results show that anti-MDA5<sup>+</sup> B cells recognize the helicase domains, which are the enzymatically active domains of the protein. These results have implications for understanding the etiopathology of anti-MDA5<sup>+</sup> DM and development of new antigen-specific therapies.
Authors
- Gräslund Susanne
- Michael Szardenings
- Karolin Kern (ORCID: https://orcid.org/0000-0002-1233-7175)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Deniz Demirdal
- Ragnhild Stålesen
- Karine Chemin (ORCID: https://orcid.org/0000-0002-2597-7809)
- Annika van Vollenhoven
- Nicolas Delaroque (ORCID: https://orcid.org/0000-0003-4302-8233)
- Vijay Joshua
- Marina Galesic
- Eveline van Gompel
- Vivianne Malmström
- Monika Hansson
- Caroline Grönwall
- Ingrid E. Lundberg
- Antonella Notarnicola
- Edvard Wigren
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Fraunhofer Institute for Cell Therapy and Immunology (DE)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.jaut.2026.103536
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00