Astragaloside IV ameliorates cognitive impairment in heart failure rats via modulation of RAGE‐ERK1/2‐NF‐ <i>κ</i> B signalling pathway
AS-IV enhances cognitive function of HF rats by inhibiting the RAGE-ERK1/2-NF-κB signalling pathway to reduce inflammation and apoptosis and thereby improve synaptic function. AS-IV emerges as a promising candidate for the prevention and treatment of HF-CI.
Authors
- Xiaowan Han
- Weibing Pan
- Shaojiao Liu
- Jie Chen (ORCID: https://orcid.org/0000-0003-3435-0351)
- Yutong Li
- Lei Wang
- Yu Teng
- Mingjing Zhao
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1111/bph.70368
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00