The use of human decellularized amniotic membrane as pulmonary valve leaflets in right ventricular outflow tract reconstruction – an in vivo proof of concept study
This study provides an <i>in vivo</i> proof of concept that the decellularized amniotic membrane can be implanted and perform as functional pulmonary valve in a porcine animal model mimicking the clinical scenario of Tetralogy of Fallot surgical correction in infants.
Authors
- Sofia Di Leonardo (ORCID: https://orcid.org/0000-0003-0689-1396)
- Danila Vella (ORCID: https://orcid.org/0000-0001-6251-3651)
- Dominga Iacobazzi (ORCID: https://orcid.org/0000-0001-5977-0518)
- Mohamed Ghorbel (ORCID: https://orcid.org/0000-0003-0821-0398)
- Katie L. Skeffington (ORCID: https://orcid.org/0000-0001-5252-6459)
- Giulia Parolari
- Tasneem Salih
- Massimo Caputo
Institutions
- Bristol Royal Hospital for Children (GB)
- University of Bristol (GB)
- University of Palermo (AR)
- Ri.MED (IT)
- University College London (GB)
- University of Palermo (IT)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fbioe.2026.1735821
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00