VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy
The findings herein underscore the pivotal role of EV-derived VDAC1 in driving PTX resistance in GC through dual modulation of autophagy and mitophagy, mediated by the AMPK/mTOR signaling axis. Targeting EV-derived VDAC1 has emerged as a promising therapeutic strategy to counteract chemoresistance, providing a novel avenue for improving GC treatment outcomes.
Authors
- Yanna Bi (ORCID: https://orcid.org/0000-0002-0619-0242)
- Guogui Sun
- Yumin Wang
- Sisi Wei
- Zhe Zhang
- Kexin Li
- Yuqing Wang
- Lianmei Zhao
- Cong Zhang
- Yang Wen
Institutions
- Hebei Medical University (CN)
- North China University of Science and Technology (CN)
- Peking University (CN)
- Fourth Hospital of Hebei Medical University (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
- Aerospace Center Hospital (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-02-17
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0360
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China