Association between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study
Competing-risk analysis showed that NEC risk may be inversely associated with short-term IEAT in the whole cohort and the non-low-risk EOS group. Notably, the risk of NEC tended to be higher with prolonged IEAT duration in very preterm infants at different EOS risk. These associational findings are exploratory and warrant further investigation.
Authors
- Xiaolu Ma (ORCID: https://orcid.org/0000-0002-2392-1510)
- SanNan WANG
- Xinnian Pan
- Jianhua Fu (ORCID: https://orcid.org/0000-0003-0660-4211)
- Bin Yi (ORCID: https://orcid.org/0000-0002-9239-8639)
- Bin Wang (ORCID: https://orcid.org/0000-0001-9496-0210)
- Jie Yang (ORCID: https://orcid.org/0000-0003-1839-5891)
- Zhen Li (ORCID: https://orcid.org/0000-0002-8732-0714)
- Yong Ji (ORCID: https://orcid.org/0000-0002-0702-3286)
- Liyan Zhang (ORCID: https://orcid.org/0000-0001-6549-664X)
- Yuan Shi (ORCID: https://orcid.org/0009-0006-7707-080X)
- Hongyun Wang
- Lizhong Du
- Falin Xu
- Huayan Zhang
- Yun Cao
- Xiaoying Li
- Xiuying Tian
- Jiahua Pan
- Zhankui Li
- Xirong Gang
- Huaiyan Wang
- Gang Qiu
- Dongmei Chen
- Yanhong Li
- Li Li
- Chuanzhong Yang
- Xinyue Gu
- Qin Zhou
- Yinquan Xu
- Mingxia Li
- Jinxing Feng
- Hong Jiang
- Hui Wu
- Zhen Wang
- Ruobing Shan
- Xiuyong Chen
- Lili Wang
- Kun Liang
- Yan Gao
- Ling Liu
- Shuping Han
- Hongdan Zhu
- Yiheng Dai
- Hongxia Song
- Wenhao Zhou
- Chao Chen
- Li Ma
- Long Li
- Changyi Yang
- Hongying Mi
- Qianshen Zhang
- Jianhua Sun
- Xiaoyun Zhong
- Wenqing Kang
- Deyi Zhuang
- Ling Yang
- Chinese Neonatal Network
- Zhenlang Lin
- Fang Wu
- Xing Feng
- Hong Zhen
- Zhaoqing Yin
- Rui Cheng
- Jimei Wang
- Wenbin Dong
- Pingyang Chen
- Shoo K. Lee
- Dong Li
- Linkong Zeng
- Hongping Xia
- Qin Zhang
Institutions
- University of Toronto (CA)
- Jilin University (CN)
- Health Commission of Jilin Province (CN)
- First Hospital of Jilin University (CN)
- Children's Hospital of Fudan University (CN)
- Ningbo No.6 Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1186/s12884-026-08798-8
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00