Molecular epidemiological association between antimicrobial resistance characteristics and type III secretion system in carbapenem-resistant Pseudomonas aeruginosa from lower respiratory tract infections
<i>ExoU</i>+/<i>exoS</i>- strains were strongly associated with resistance genes like <i>bla</i> <sub>KPC-3</sub>,<i>bla</i> <sub>OXA-488</sub>, <i>bla</i> <sub>OXA-1032</sub>, ICU admission and exhibited a more pronounced drug-resistant phenotype. Potential high-risk clones such as ST1076-O11 and ST463-O4 display both extensive resistance and high virulence, underscoring the clinical and public health importance of enhanced surveillance and effective containment.
Authors
- F. Wang
- Yanzi Chang
- Hong Li
- Yun Zhou
- Chen Huang
- Ximing Wang
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.3389/fcimb.2026.1757868
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province